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Polynucleotides
3 Polynucleotide treatments
Polynucleotides in Cheltenham
Restore, repair, and regenerate your skin at a cellular level with Polynucleotide injections at Skin Redefined. This next-generation skin treatment goes beyond hydration and surface-level results — working deep within your skin to stimulate regeneration, collagen repair damaged cells, and improve overall skin health.
What Are Polynucleotides?
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Polynucleotides are biostimulating injectables made from fragments of purified DNA. Unlike dermal fillers, which add volume, or skin boosters, which hydrate, Polynucleotides actively repair and regenerate your skin from within.
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They work by:
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Stimulating fibroblasts to produce more collagen and elastin
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Improving hydration and elasticity
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Reducing inflammation and oxidative stress in the skin
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Supporting tissue repair for healthier, stronger skin
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Stimulating the production of more fibroblasts, think of this as lots of extra collagen factories in the skin
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In short, Polynucleotides don’t just make your skin look better, they actually make it function better.
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How Do Polynucleotides Differ From Other Skin Boosters?
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Traditional skin boosters (like hyaluronic acid) provide hydration and a dewy glow, but their effects are often temporary. Polynucleotides go much further, actively repairing DNA damage, encouraging long-term collagen production, and tackling issues linked with ageing, sun exposure, and inflammation.
This makes them especially effective for concerns like fine lines, wrinkles, under-eye bags, and crepey or sagging skin — areas where standard boosters may not deliver enough improvement.
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Benefits of Polynucleotide Injections
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Improves skin elasticity and firmness
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Reduces wrinkles and fine lines
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Revitalises tired, dull, or ageing skin
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Helps with under-eye concerns such as puffiness or dark circles
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Repairs UV and oxidative damage
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Calms inflammation (ideal for rosacea-prone skin)
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Provides long-lasting results with cumulative benefits
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What areas can polynucleotides treat?
Polynucleotides can be used anywhere you have skin, this includes upper and lower eyelids which is generally a no-go area when it comes to most injectable treatments. Common areas for treatment include:
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Saggy neck
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Eye bags, loose skin on the upper eyelids
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Dark circles
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General skin improvement on the face- wrinkles, pores, acne, hyper-pigmentation, rosacea.
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Chest
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Scars from acne, surgery, or trauma.
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Loose, crepey skin on the upper arms or belly. ​​​
Polynucleotides
Frequently Asked Questions
How many Polynucleotide treatments will I need?
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We usually recommend a course of 2–3 treatments, spaced a few weeks apart, for the best results. Many clients notice improvements in texture and hydration after the first session.
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Are Polynucleotide injections painful?
The treatment is generally well tolerated. A fine needle is used, and a numbing cream can be applied for extra comfort.
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What does skin look like after Polynucleotide treatment?
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You may experience a little redness or mild swelling at the injection points, which usually settles within 24–48 hours. Most people return to normal activities straight away.
When will I see results from Polynucleotides?
Results build gradually as your skin repairs itself. You can expect noticeable improvements in texture, elasticity, and overall radiance within a few weeks, with continued progress over several months.
How long do Polynucleotide results last?
The results typically last around 6–12 months, depending on your skin and lifestyle. Many clients choose to maintain results with top-up sessions once or twice a year.
Which areas can Polynucleotides treat?
Polynucleotides are especially effective for delicate areas such as the under-eyes, as well as the face, neck, décolletage, and hands.
How can I boost my Polynucleotide results?
Pairing your treatment with AlumierMD medical-grade skincare Helps protect and maintain your skin health, giving you longer-lasting results.
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How Much Do Polynucleotides Cost? ​
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Polynucleotides can be used for target a specific area of the face, neck or body. For a small targeted area, for example around the eyes to treat dark circles, eye bags or crows feet, this is charged at £250. For full face rejuvenation or full neck this is £450. A course of 2-3 sessions is usually recommended, up to 4 for advanced ageing. Click book appointment to view the full price list or book a consultation to find out more.