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Get That Radiant Glow with Polynucleotides!

Welcome to my blog! This week, I'll be explaining a groundbreaking treatment that I've recently introduced that can rejuvenate your skin like never before: polynucleotides. These natural substances, often referred to as PDRN (Polydeoxyribonucleotide), are derived from salmon or trout DNA and are making waves in the skincare world. Read on to find out what it's all about.

What do polynucleotides do?

Polynucleotides are your skin's new best friend. They work by stimulating

collagen production and promoting cell regeneration. Collagen is the building block of youthful skin, giving it that firm, elastic feel. As we age, our natural collagen prouction decreases, leading to wrinkles, fine lines, and sagging skin. Polynucleotides attach to our fibroblast cells to boost collagen synthesis, helping to restore your skin’s youthful appearance.

These cells are responsible for producing the supportive and hydrating elements within our skin, the collagen, elastin and hyaluronic acid. When polynucleotides are injected, the DNA locks onto these cells, effectively supercharging them. The treatment also triggers even more fibroblast cells to be produced. As a result, we not only have cells that are working more effectively, but there are much more of them.

Polynucleotides can make your skin look and feel younger and healthier in the following ways:

  • Smooths and Firms: Polynucleotides help smooth out fine lines and wrinkles, giving your skin a firmer, more youthful texture.

  • Hydrates Like Magic: They boost skin hydration levels, leaving your skin looking fresh, dewy, and radiant.

  • Brightens Up: Polynucleotides can help fade dark spots and pigmentation, resulting in a more even skin tone.

  • Heals and Repairs: Their anti-inflammatory properties accelerate wound healing and reduce redness and swelling.

Polynucleotides also have anti-inflammatory properties, which help reduce redness and swelling. They enhance the skin's healing process, making them effective for treating various skin conditions and injuries.

Where can polycucleotides be used?

The beauty of polynucleotides is that they are a very versatile treatment and can be used anywhere there is skin! The most common areas for treatment are:

  • Crows feet

  • Eye bags

  • Lip lines

  • Saggy neck and neck lines

  • Scarring- new and old

  • Lines and wrinkles on the face

  • Enlarged pores

  • Dark circles

  • Hyperpigmentation- age spots, melasma, sun damaged skin.

What happens during a polynucleotide treatment?

Polynucleotides need to be injected into the deep layers of our skin in order to be effective. This can be done in various ways:

  • Micro-bolus: Tiny injections deliver polynucleotides directly into the skin, targeting specific areas of concern. This leaves tiny bumps that look like nettle stings that may last for a day or two.

  • Injection with a cannula: This is a blunt ended needle inserted under the skin to spread out the product. A more gentle approach for sensitive areas.

  • Microneedling: This procedure creates tiny punctures in the skin, allowing polynucleotides to penetrate deeper and work more effectively. This means that the product can be administered over a wider area for overall skin improvement. Polynucleotides with microneedling can be a very effective treatment combination.

Polynucleotides before and after

Don't just take our word for it—check out these incredible before and after photos from real patients who have experienced the transformative effects of polynucleotide treatments. Expect to see smoother, more hydrated, and rejuvenated skin that speaks for itself.



Polynucleotides can work fantastically well with other treatments, some can even be performed on the same day. In fact, it has been shown that polynucleotides can enhance the results and longevity of other treatments. For example, collagen stimulating treatments such as chemical peels, microneedling and radiofrequency microneedling will be more effective when given alongside a course of polynucleotides due to the pre conditioned skin, and the increased number of fibroblasts to make collagen.

Dermal fillers and botox will also be more effective if the skin is pre-conditioned with polynucleotides. Injectable treatments always look better on healthy skin. Imagine putting up a beautiful oil painting on a lack lustre wall, with peeling paint and holes in the plaster? It just wouldn't look as good.


Ready to Glow? 


If you're curious about trying polynucleotides for your skin, book a no-obligation consultation at my Cheltenham Clinic,


Kelly Whittaker

Advanced Aesthetics Nurse

Independent Prescriber

Clinical Director



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